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O Brother, Where Art Thou? is a 2000 comedy drama film. It stars George Clooney, John Turturro, and Tim Blake Nelson, with Chris Thomas King, John Goodman, Holly Hunter, and Charles Durning in supporting roles.The film is set in rural Mississippi during the 1930s, and it follows three escaped convicts searching for hidden treasure while a sheriff relentlessly pursues them. Its story is a modern satire loosely based on Homer's epic Greek poem the Odyssey.